Dual use of hematopoietic and mesenchymal stem cells enhances engraftment and immune cell trafficking in an allogeneic humanized mouse model of head and neck cancer

The need for more representative tools to investigate the human tumor microenvironment (TME) has led to the development of humanized mouse models. However, the difficulty of immune system engraftment and minimal human immune cell infiltration into implanted xenografts are major challenges. We have d...

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Bibliographic Details
Published in:Mol Carcinog
Main Authors: Morton, J. Jason, Keysar, Stephen B., Perrenoud, Loni, Chimed, Tugs-Saikhan, Reisinger, Julie, Jackson, Brian, Le, Phuong N., Nieto, Cera, Gomez, Karina, Miller, Bettina, Gao, Dexiang, Somerset, Hilary, Wang, Xiao-Jing, Jimeno, Antonio
Format: Artigo
Language:Inglês
Published: 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6452868/
https://ncbi.nlm.nih.gov/pubmed/30129680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mc.22887
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