Dual use of hematopoietic and mesenchymal stem cells enhances engraftment and immune cell trafficking in an allogeneic humanized mouse model of head and neck cancer

The need for more representative tools to investigate the human tumor microenvironment (TME) has led to the development of humanized mouse models. However, the difficulty of immune system engraftment and minimal human immune cell infiltration into implanted xenografts are major challenges. We have d...

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Gepubliceerd in:Mol Carcinog
Hoofdauteurs: Morton, J. Jason, Keysar, Stephen B., Perrenoud, Loni, Chimed, Tugs-Saikhan, Reisinger, Julie, Jackson, Brian, Le, Phuong N., Nieto, Cera, Gomez, Karina, Miller, Bettina, Gao, Dexiang, Somerset, Hilary, Wang, Xiao-Jing, Jimeno, Antonio
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6452868/
https://ncbi.nlm.nih.gov/pubmed/30129680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mc.22887
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