Inhibiting translation elongation with SVC112 suppresses cancer stem cells and inhibits growth in head and neck squamous carcinoma

Cancer stem cells (CSCs) drive growth, therapy resistance, and recurrence in head and neck squamous cell carcinoma (HNSCC). Regulation of protein translation is crucial for normal stem cells and CSCs; its inhibition could disrupt stemness properties, but translation inhibitors are limited clinically...

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Publicado no:Cancer Res
Main Authors: Keysar, Stephen B., Gomes, Nathan, Miller, Bettina, Jackson, Brian C., Le, Phuong N., Morton, J. Jason, Reisinger, Julie, Chimed, Tugs-Saikhan, Gomez, Karina E., Nieto, Cera, Frederick, Barbara, Pronk, Gijsbertus J., Somerset, Hilary L., Tan, Aik-Choon, Wang, Xiao-Jing, Raben, David, Su, Tin Tin, Jimeno, Antonio
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7056512/
https://ncbi.nlm.nih.gov/pubmed/31911553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-19-3232
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