Studying immunotherapy resistance in a melanoma autologous humanized mouse xenograft.

Resistance to immunotherapy is a significant challenge, and the scarcity of human models hinders the identification of the underlying mechanisms. To address this limitation, we constructed an autologous humanized mouse (aHM) model with hematopoietic stem and progenitor cells (HSPCs) and tumors from...

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Publicado en:Mol Cancer Res
Autores principales: Morton, J. Jason, Alzofon, Nathaniel, Keysar, Stephen B., Chimed, Tugs-Saikhan, Reisinger, Julie, Perrenoud, Loni, Le, Phuong N., Nieto, Cera, Gomez, Karina, Miller, Bettina, Yeager, Randi, Gao, Dexiang, Tan, Aik-Choon, Somerset, Hilary, Medina, Theresa, Wang, Xiao-Jing, Wang, Jing H., Robinson, William, Roop, Dennis R., Gonzalez, Rene, Jimeno, Antonio
Formato: Artigo
Lenguaje:Inglês
Publicado: 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7864867/
https://ncbi.nlm.nih.gov/pubmed/33087417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-20-0686
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