Studying immunotherapy resistance in a melanoma autologous humanized mouse xenograft.

Resistance to immunotherapy is a significant challenge, and the scarcity of human models hinders the identification of the underlying mechanisms. To address this limitation, we constructed an autologous humanized mouse (aHM) model with hematopoietic stem and progenitor cells (HSPCs) and tumors from...

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Detalhes bibliográficos
Publicado no:Mol Cancer Res
Main Authors: Morton, J. Jason, Alzofon, Nathaniel, Keysar, Stephen B., Chimed, Tugs-Saikhan, Reisinger, Julie, Perrenoud, Loni, Le, Phuong N., Nieto, Cera, Gomez, Karina, Miller, Bettina, Yeager, Randi, Gao, Dexiang, Tan, Aik-Choon, Somerset, Hilary, Medina, Theresa, Wang, Xiao-Jing, Wang, Jing H., Robinson, William, Roop, Dennis R., Gonzalez, Rene, Jimeno, Antonio
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7864867/
https://ncbi.nlm.nih.gov/pubmed/33087417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-20-0686
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