Cancer cell CD44 mediates macrophage/monocyte-driven regulation of head and neck cancer stem cells

Tumor-associated macrophages (TAM) in the tumor microenvironment (TME) cooperate with cancer stem cells (CSC) to maintain stemness. We recently identified CD44 as a surface marker defining head and neck squamous cell carcinoma (HNSCC) CSC. PI3K-4EBP1-SOX2 activation and signaling regulate CSC proper...

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Detalhes bibliográficos
Publicado no:Cancer Res
Principais autores: Gomez, Karina E., Wu, FangLong, Keysar, Stephen B., Morton, J. Jason, Miller, Bettina, Chimed, Tugs-Saikhan, Le, Phuong N., Nieto, Cera, Chowdhury, Farshad N., Tyagi, Anit, Lyons, Traci R., Young, Christian D., Zhou, Hongmei, Somerset, Hilary L., Wang, Xiao-Jing, Jimeno, Antonio
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8146866/
https://ncbi.nlm.nih.gov/pubmed/32816856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-20-1079
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