Population Pharmacokinetics of Fludarabine in Children and Adults during Conditioning Prior to Allogeneic Hematopoietic Cell Transplantation

BACKGROUND: Fludarabine is often used as an important drug in reduced toxicity conditioning regimens prior to hematopoietic cell transplantation (HCT). As no definitive pharmacokinetic (PK) basis for HCT dosing for the wide age and weight range in HCT is available, linear body surface area (BSA)-bas...

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Udgivet i:Clin Pharmacokinet
Main Authors: Langenhorst, Jurgen B., Dorlo, Thomas P. C., van Maarseveen, Erik M., Nierkens, Stefan, Kuball, Jürgen, Boelens, Jaap Jan, van Kesteren, Charlotte, Huitema, Alwin D. R.
Format: Artigo
Sprog:Inglês
Udgivet: Springer International Publishing 2018
Fag:
Original Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6451721/
https://ncbi.nlm.nih.gov/pubmed/30327943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40262-018-0715-9
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