A semi‐mechanistic model based on glutathione depletion to describe intra‐individual reduction in busulfan clearance

AIM: To develop a semi‐mechanistic model, based on glutathione depletion and predict a previously identified intra‐individual reduction in busulfan clearance to aid in more precise dosing. METHODS: Busulfan concentration data, measured as part of regular care for allogeneic hematopoietic cell transp...

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Detalhes bibliográficos
Publicado no:Br J Clin Pharmacol
Main Authors: Langenhorst, Jurgen B., Boss, Jill, van Kesteren, Charlotte, Lalmohamed, Arief, Kuball, Jürgen, Egberts, Antoine C. G., Boelens, Jaap Jan, Huitema, Alwin D. R., van Maarseveen, Erik M.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7373715/
https://ncbi.nlm.nih.gov/pubmed/32067250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.14256
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