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Nonlinear protein binding of phenytoin in clinical practice: Development and validation of a mechanistic prediction model
AIMS: To individualize treatment, phenytoin doses are adjusted based on free concentrations, either measured or calculated from total concentrations. As a mechanistic protein binding model may more accurately reflect the protein binding of phenytoin than the empirical Winter–Tozer equation that is r...
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| Publicado no: | Br J Clin Pharmacol |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6783592/ https://ncbi.nlm.nih.gov/pubmed/31269540 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.14053 |
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