Nonlinear protein binding of phenytoin in clinical practice: Development and validation of a mechanistic prediction model

AIMS: To individualize treatment, phenytoin doses are adjusted based on free concentrations, either measured or calculated from total concentrations. As a mechanistic protein binding model may more accurately reflect the protein binding of phenytoin than the empirical Winter–Tozer equation that is r...

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Veröffentlicht in:Br J Clin Pharmacol
Hauptverfasser: ter Heine, Rob, Kane, Sean P., Huitema, Alwin D.R., Krasowski, Matthew D., van Maarseveen, Erik M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2019
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6783592/
https://ncbi.nlm.nih.gov/pubmed/31269540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.14053
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