A guardian residue hinders insertion of a Fapy•dGTP analog by modulating the open-closed DNA polymerase transition

4,6-Diamino-5-formamidopyrimidine (Fapy•dG) is an abundant form of oxidative DNA damage that is mutagenic and contributes to the pathogenesis of human disease. When Fapy•dG is in its nucleotide triphosphate form, Fapy•dGTP, it is inefficiently cleansed from the nucleotide pool by the responsible enz...

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Publicat a:Nucleic Acids Res
Autors principals: Smith, Mallory R, Shock, David D, Beard, William A, Greenberg, Marc M, Freudenthal, Bret D, Wilson, Samuel H
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2019
Matèries:
Structural Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6451102/
https://ncbi.nlm.nih.gov/pubmed/30649431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz002
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