Structures of a DNA Polymerase Inserting Therapeutic Nucleotide Analogues

Members of the nucleoside analogue class of cancer therapeutics compete with canonical nucleotides to disrupt numerous cellular processes, including nucleotide homeostasis, DNA and RNA synthesis, and nucleotide metabolism. Nucleoside analogues are triphosphorylated and subsequently inserted into gen...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Chem Res Toxicol
Egile Nagusiak: Schaich, Matthew A., Smith, Mallory R., Cloud, Ashley S., Holloran, Sean M., Freudenthal, Bret D.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2017
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6494084/
https://ncbi.nlm.nih.gov/pubmed/28862449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrestox.7b00173
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