Structures of a DNA Polymerase Inserting Therapeutic Nucleotide Analogues

Members of the nucleoside analogue class of cancer therapeutics compete with canonical nucleotides to disrupt numerous cellular processes, including nucleotide homeostasis, DNA and RNA synthesis, and nucleotide metabolism. Nucleoside analogues are triphosphorylated and subsequently inserted into gen...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Chem Res Toxicol
Main Authors: Schaich, Matthew A., Smith, Mallory R., Cloud, Ashley S., Holloran, Sean M., Freudenthal, Bret D.
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6494084/
https://ncbi.nlm.nih.gov/pubmed/28862449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrestox.7b00173
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