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Capturing a mammalian DNA polymerase extending from an oxidized nucleotide

The oxidized nucleotide, 8-oxo-7,8-dihydro-2΄-deoxyguanosine (8-oxoG), is one of the most abundant DNA lesions. 8-oxoG plays a major role in tumorigenesis and human disease. Biological consequences of 8-oxoG are mediated in part by its insertion into the genome, making it essential to understand how...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nucleic Acids Res
Prif Awduron: Whitaker, Amy M., Smith, Mallory R., Schaich, Matthew A., Freudenthal, Bret D.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2017
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5499815/
https://ncbi.nlm.nih.gov/pubmed/28449123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx293
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