Structures of a DNA Polymerase Inserting Therapeutic Nucleotide Analogues

Members of the nucleoside analogue class of cancer therapeutics compete with canonical nucleotides to disrupt numerous cellular processes, including nucleotide homeostasis, DNA and RNA synthesis, and nucleotide metabolism. Nucleoside analogues are triphosphorylated and subsequently inserted into gen...

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Detaylı Bibliyografya
Yayımlandı:Chem Res Toxicol
Asıl Yazarlar: Schaich, Matthew A., Smith, Mallory R., Cloud, Ashley S., Holloran, Sean M., Freudenthal, Bret D.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2017
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6494084/
https://ncbi.nlm.nih.gov/pubmed/28862449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrestox.7b00173
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