A guardian residue hinders insertion of a Fapy•dGTP analog by modulating the open-closed DNA polymerase transition

4,6-Diamino-5-formamidopyrimidine (Fapy•dG) is an abundant form of oxidative DNA damage that is mutagenic and contributes to the pathogenesis of human disease. When Fapy•dG is in its nucleotide triphosphate form, Fapy•dGTP, it is inefficiently cleansed from the nucleotide pool by the responsible enz...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Smith, Mallory R, Shock, David D, Beard, William A, Greenberg, Marc M, Freudenthal, Bret D, Wilson, Samuel H
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2019
Témata:
Structural Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6451102/
https://ncbi.nlm.nih.gov/pubmed/30649431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz002
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