A guardian residue hinders insertion of a Fapy•dGTP analog by modulating the open-closed DNA polymerase transition

4,6-Diamino-5-formamidopyrimidine (Fapy•dG) is an abundant form of oxidative DNA damage that is mutagenic and contributes to the pathogenesis of human disease. When Fapy•dG is in its nucleotide triphosphate form, Fapy•dGTP, it is inefficiently cleansed from the nucleotide pool by the responsible enz...

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Bibliographische Detailangaben
Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Smith, Mallory R, Shock, David D, Beard, William A, Greenberg, Marc M, Freudenthal, Bret D, Wilson, Samuel H
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2019
Schlagworte:
Structural Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6451102/
https://ncbi.nlm.nih.gov/pubmed/30649431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz002
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