A guardian residue hinders insertion of a Fapy•dGTP analog by modulating the open-closed DNA polymerase transition

4,6-Diamino-5-formamidopyrimidine (Fapy•dG) is an abundant form of oxidative DNA damage that is mutagenic and contributes to the pathogenesis of human disease. When Fapy•dG is in its nucleotide triphosphate form, Fapy•dGTP, it is inefficiently cleansed from the nucleotide pool by the responsible enz...

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Bibliografiske detaljer
Udgivet i:Nucleic Acids Res
Main Authors: Smith, Mallory R, Shock, David D, Beard, William A, Greenberg, Marc M, Freudenthal, Bret D, Wilson, Samuel H
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2019
Fag:
Structural Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6451102/
https://ncbi.nlm.nih.gov/pubmed/30649431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz002
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