A guardian residue hinders insertion of a Fapy•dGTP analog by modulating the open-closed DNA polymerase transition

4,6-Diamino-5-formamidopyrimidine (Fapy•dG) is an abundant form of oxidative DNA damage that is mutagenic and contributes to the pathogenesis of human disease. When Fapy•dG is in its nucleotide triphosphate form, Fapy•dGTP, it is inefficiently cleansed from the nucleotide pool by the responsible enz...

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Detaylı Bibliyografya
Yayımlandı:Nucleic Acids Res
Asıl Yazarlar: Smith, Mallory R, Shock, David D, Beard, William A, Greenberg, Marc M, Freudenthal, Bret D, Wilson, Samuel H
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2019
Konular:
Structural Biology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6451102/
https://ncbi.nlm.nih.gov/pubmed/30649431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz002
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