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The human HOXA9 protein uses paralog-specific residues of the homeodomain to interact with TALE-class cofactors

HOX proteins interact with PBX and MEIS cofactors, which belong to the TALE-class of homeodomain (HD)-containing transcription factors. Although the formation of HOX-PBX complexes depends on a unique conserved HOX motif called hexapeptide (HX), the additional presence of MEIS induces a remodeling of...

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Bibliografski detalji
Izdano u:Sci Rep
Glavni autori: Dard, Amélie, Jia, Yunlong, Reboulet, Jonathan, Bleicher, Françoise, Lavau, Catherine, Merabet, Samir
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2019
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6450960/
https://ncbi.nlm.nih.gov/pubmed/30952900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-42096-y
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