CHP1 regulates compartmentalized glycerolipid synthesis by activating GPAT4

Cells require a constant supply of fatty acids to survive and proliferate. Fatty acids incorporate into membrane and storage glycerolipids through a series of endoplasmic reticulum (ER) enzymes, but how these enzymes are regulated is not well understood. Here, using a combination of CRISPR-based gen...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Zhu, Xiphias Ge, Puthenveedu, Shirony Nicholson, Shen, Yihui, La, Konnor, Ozlu, Can, Wang, Tim, Klompstra, Diana, Gultekin, Yetis, Chi, Jingyi, Fidelin, Justine, Peng, Tao, Molina, Henrik, Hang, Howard C., Min, Wei, Birsoy, Kıvanç
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6450717/
https://ncbi.nlm.nih.gov/pubmed/30846317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.01.037
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