CHP1 regulates compartmentalized glycerolipid synthesis by activating GPAT4

Cells require a constant supply of fatty acids to survive and proliferate. Fatty acids incorporate into membrane and storage glycerolipids through a series of endoplasmic reticulum (ER) enzymes, but how these enzymes are regulated is not well understood. Here, using a combination of CRISPR-based gen...

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Bibliografiska uppgifter
I publikationen:Mol Cell
Huvudupphovsmän: Zhu, Xiphias Ge, Puthenveedu, Shirony Nicholson, Shen, Yihui, La, Konnor, Ozlu, Can, Wang, Tim, Klompstra, Diana, Gultekin, Yetis, Chi, Jingyi, Fidelin, Justine, Peng, Tao, Molina, Henrik, Hang, Howard C., Min, Wei, Birsoy, Kıvanç
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2019
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6450717/
https://ncbi.nlm.nih.gov/pubmed/30846317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.01.037
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