Generation of single-copy transgenic mouse embryos directly from ES cells by tetraploid embryo complementation

BACKGROUND: Transgenic mice have been used extensively to analyze gene function. Unfortunately, traditional transgenic procedures have only limited use in analyzing alleles that cause lethality because lines of founder mice cannot be established. This is frustrating given that such alleles often rev...

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Hlavní autoři: Misra, Ravi P, Bronson, Sarah K, Xiao, Qi, Garrison, Wendy, Li, Jixuan, Zhao, Roong, Duncan, Stephen A
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2001
Témata:
Methodology Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC64498/
https://ncbi.nlm.nih.gov/pubmed/11782291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6750-1-12
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