Generation of single-copy transgenic mouse embryos directly from ES cells by tetraploid embryo complementation

BACKGROUND: Transgenic mice have been used extensively to analyze gene function. Unfortunately, traditional transgenic procedures have only limited use in analyzing alleles that cause lethality because lines of founder mice cannot be established. This is frustrating given that such alleles often rev...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Misra, Ravi P, Bronson, Sarah K, Xiao, Qi, Garrison, Wendy, Li, Jixuan, Zhao, Roong, Duncan, Stephen A
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2001
Sujets:
Methodology Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC64498/
https://ncbi.nlm.nih.gov/pubmed/11782291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6750-1-12
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