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Efficiency measures the conversion of agonist binding energy into receptor conformational change
Receptors alternate between resting↔active conformations that bind agonists with low↔high affinity. Here, we define a new agonist attribute, energy efficiency (η), as the fraction of ligand-binding energy converted into the mechanical work of the activation conformational change. η depends only on t...
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| Publicado no: | J Gen Physiol |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Rockefeller University Press
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6445574/ https://ncbi.nlm.nih.gov/pubmed/30635369 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201812215 |
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