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Synthesis of an acridine orange sulfonamide derivative with potent carbonic anhydrase IX inhibitory action

Acridine orange (AO) a fluorescent cationic dye used for the management of human musculoskeletal sarcomas, due to its strong tumoricidal action and accumulation in the acidic environment typical of hypoxic tumors, was used for the preparation of a primary sulfonamide derivative. The rationale behind...

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Detalhes bibliográficos
Publicado no:J Enzyme Inhib Med Chem
Main Authors: Bragagni, Marco, Carta, Fabrizio, Osman, Sameh M., AlOthman, Zeid, Supuran, Claudiu T.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6445237/
https://ncbi.nlm.nih.gov/pubmed/28335646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2017.1302441
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