Concurrent inhibition of Pim and FLT3 kinases enhances apoptosis of FLT3-ITD acute myeloid leukemia cells through increased Mcl-1 proteasomal degradation

PURPOSE: fms-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD) is present in 30% of acute myeloid leukemia (AML), and these patients have short disease-free survival. FLT3 inhibitors have limited and transient clinical activity, and concurrent treatment with inhibitors of parallel or dow...

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Detaylı Bibliyografya
Yayımlandı:Clin Cancer Res
Asıl Yazarlar: Kapoor, Shivani, Natarajan, Karthika, Baldwin, Patrick R., Doshi, Kshama A., Lapidus, Rena G., Mathias, Trevor J., Scarpa, Mario, Trotta, Rossana, Davila, Eduardo, Kraus, Manfred, Huszar, Dennis, Tron, Adriana E., Perrotti, Danilo, Baer, Maria R.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2017
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6444348/
https://ncbi.nlm.nih.gov/pubmed/29074603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-1629
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