TET2 binding to enhancers facilitates transcription factor recruitment in hematopoietic cells

The epigenetic regulator TET2 is frequently mutated in hematological diseases. Mutations have been shown to arise in hematopoietic stem cells early in disease development and lead to altered DNA methylation landscapes and an increased risk of hematopoietic malignancy. Here, we show by genome-wide ma...

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Detalhes bibliográficos
Publicado no:Genome Res
Main Authors: Rasmussen, Kasper D., Berest, Ivan, Keβler, Sandra, Nishimura, Koutarou, Simón-Carrasco, Lucía, Vassiliou, George S., Pedersen, Marianne T., Christensen, Jesper, Zaugg, Judith B., Helin, Kristian
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6442383/
https://ncbi.nlm.nih.gov/pubmed/30796038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.239277.118
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