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The KDM4/JMJD2 histone demethylases are required for hematopoietic stem cell maintenance
KDM4/JMJD2 are H3K9- and H3K36-specific demethylases, which are considered promising therapeutic targets for the treatment of acute myeloid leukemia (AML) harboring MLL translocations. Here, we investigate the long-term effects of depleting KDM4 activity on normal hematopoiesis to probe potential si...
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| Pubblicato in: | Blood |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society of Hematology
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6776794/ https://ncbi.nlm.nih.gov/pubmed/31434704 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019000855 |
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