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The KDM4/JMJD2 histone demethylases are required for hematopoietic stem cell maintenance

KDM4/JMJD2 are H3K9- and H3K36-specific demethylases, which are considered promising therapeutic targets for the treatment of acute myeloid leukemia (AML) harboring MLL translocations. Here, we investigate the long-term effects of depleting KDM4 activity on normal hematopoiesis to probe potential si...

詳細記述

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書誌詳細
出版年:Blood
主要な著者: Agger, Karl, Nishimura, Koutarou, Miyagi, Satoru, Messling, Jan-Erik, Rasmussen, Kasper Dindler, Helin, Kristian
フォーマット: Artigo
言語:Inglês
出版事項: American Society of Hematology 2019
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6776794/
https://ncbi.nlm.nih.gov/pubmed/31434704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019000855
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