The KDM4/JMJD2 histone demethylases are required for hematopoietic stem cell maintenance

KDM4/JMJD2 are H3K9- and H3K36-specific demethylases, which are considered promising therapeutic targets for the treatment of acute myeloid leukemia (AML) harboring MLL translocations. Here, we investigate the long-term effects of depleting KDM4 activity on normal hematopoiesis to probe potential si...

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Dettagli Bibliografici
Pubblicato in:Blood
Autori principali: Agger, Karl, Nishimura, Koutarou, Miyagi, Satoru, Messling, Jan-Erik, Rasmussen, Kasper Dindler, Helin, Kristian
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2019
Soggetti:
Hematopoiesis and Stem Cells
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6776794/
https://ncbi.nlm.nih.gov/pubmed/31434704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019000855
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