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The KDM4/JMJD2 histone demethylases are required for hematopoietic stem cell maintenance
KDM4/JMJD2 are H3K9- and H3K36-specific demethylases, which are considered promising therapeutic targets for the treatment of acute myeloid leukemia (AML) harboring MLL translocations. Here, we investigate the long-term effects of depleting KDM4 activity on normal hematopoiesis to probe potential si...
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| 出版年: | Blood |
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| 主要な著者: | , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society of Hematology
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6776794/ https://ncbi.nlm.nih.gov/pubmed/31434704 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019000855 |
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