TET2 binding to enhancers facilitates transcription factor recruitment in hematopoietic cells

The epigenetic regulator TET2 is frequently mutated in hematological diseases. Mutations have been shown to arise in hematopoietic stem cells early in disease development and lead to altered DNA methylation landscapes and an increased risk of hematopoietic malignancy. Here, we show by genome-wide ma...

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Detalles Bibliográficos
Publicado en:Genome Res
Autores principales: Rasmussen, Kasper D., Berest, Ivan, Keβler, Sandra, Nishimura, Koutarou, Simón-Carrasco, Lucía, Vassiliou, George S., Pedersen, Marianne T., Christensen, Jesper, Zaugg, Judith B., Helin, Kristian
Formato: Artigo
Lenguaje:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2019
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6442383/
https://ncbi.nlm.nih.gov/pubmed/30796038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.239277.118
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