Loss of TET2 in hematopoietic cells leads to DNA hypermethylation of active enhancers and induction of leukemogenesis

DNA methylation is tightly regulated throughout mammalian development, and altered DNA methylation patterns are a general hallmark of cancer. The methylcytosine dioxygenase TET2 is frequently mutated in hematological disorders, including acute myeloid leukemia (AML), and has been suggested to protec...

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Dettagli Bibliografici
Pubblicato in:Genes Dev
Autori principali: Rasmussen, Kasper D., Jia, Guangshuai, Johansen, Jens V., Pedersen, Marianne T., Rapin, Nicolas, Bagger, Frederik O., Porse, Bo T., Bernard, Olivier A., Christensen, Jesper, Helin, Kristian
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2015
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4421980/
https://ncbi.nlm.nih.gov/pubmed/25886910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.260174.115
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