Loss of TET2 in hematopoietic cells leads to DNA hypermethylation of active enhancers and induction of leukemogenesis

DNA methylation is tightly regulated throughout mammalian development, and altered DNA methylation patterns are a general hallmark of cancer. The methylcytosine dioxygenase TET2 is frequently mutated in hematological disorders, including acute myeloid leukemia (AML), and has been suggested to protec...

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Publicat a:Genes Dev
Autors principals: Rasmussen, Kasper D., Jia, Guangshuai, Johansen, Jens V., Pedersen, Marianne T., Rapin, Nicolas, Bagger, Frederik O., Porse, Bo T., Bernard, Olivier A., Christensen, Jesper, Helin, Kristian
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2015
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4421980/
https://ncbi.nlm.nih.gov/pubmed/25886910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.260174.115
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