Loss of TET2 in hematopoietic cells leads to DNA hypermethylation of active enhancers and induction of leukemogenesis

DNA methylation is tightly regulated throughout mammalian development, and altered DNA methylation patterns are a general hallmark of cancer. The methylcytosine dioxygenase TET2 is frequently mutated in hematological disorders, including acute myeloid leukemia (AML), and has been suggested to protec...

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Detalles Bibliográficos
Publicado en:Genes Dev
Main Authors: Rasmussen, Kasper D., Jia, Guangshuai, Johansen, Jens V., Pedersen, Marianne T., Rapin, Nicolas, Bagger, Frederik O., Porse, Bo T., Bernard, Olivier A., Christensen, Jesper, Helin, Kristian
Formato: Artigo
Idioma:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2015
Assuntos:
Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4421980/
https://ncbi.nlm.nih.gov/pubmed/25886910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.260174.115
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