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The Demethylase JMJD2C Localizes to H3K4me3-Positive Transcription Start Sites and Is Dispensable for Embryonic Development

The histone demethylase JMJD2C, also known as KDM4C/GASC1, has activity against methylated H3K9 and H3K36 and is amplified and/or overexpressed in human cancers. By the generation of Jmjd2c knockout mice, we demonstrate that loss of Jmjd2c is compatible with cellular proliferation, embryonic stem ce...

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Autori principali: Pedersen, Marianne Terndrup, Agger, Karl, Laugesen, Anne, Johansen, Jens V., Cloos, Paul A. C., Christensen, Jesper, Helin, Kristian
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3958041/
https://ncbi.nlm.nih.gov/pubmed/24396064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00864-13
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