EGFR and Prion protein promote signaling via FOXO3a‐KLF5 resulting in clinical resistance to platinum agents in colorectal cancer

Epidermal growth factor receptor (EGFR) supports colorectal cancer progression via oncogenic signaling. Anti‐EGFR therapy is being investigated as a clinical option for colorectal cancer, and an observed interaction between EGFR and Prion protein has been detected in neuronal cells. We hypothesized...

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Veröffentlicht in:Mol Oncol
Hauptverfasser: Atkinson, Caroline J., Kawamata, Futoshi, Liu, Cheng, Ham, Sunyoung, Győrffy, Balázs, Munn, Alan L., Wei, Ming Q., Möller, Andreas, Whitehall, Vicki, Wiegmans, Adrian P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2019
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6441932/
https://ncbi.nlm.nih.gov/pubmed/30478887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1878-0261.12411
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