EGFR and Prion protein promote signaling via FOXO3a‐KLF5 resulting in clinical resistance to platinum agents in colorectal cancer

Epidermal growth factor receptor (EGFR) supports colorectal cancer progression via oncogenic signaling. Anti‐EGFR therapy is being investigated as a clinical option for colorectal cancer, and an observed interaction between EGFR and Prion protein has been detected in neuronal cells. We hypothesized...

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Detalhes bibliográficos
Publicado no:Mol Oncol
Principais autores: Atkinson, Caroline J., Kawamata, Futoshi, Liu, Cheng, Ham, Sunyoung, Győrffy, Balázs, Munn, Alan L., Wei, Ming Q., Möller, Andreas, Whitehall, Vicki, Wiegmans, Adrian P.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
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Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6441932/
https://ncbi.nlm.nih.gov/pubmed/30478887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1878-0261.12411
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