EGFR and Prion protein promote signaling via FOXO3a‐KLF5 resulting in clinical resistance to platinum agents in colorectal cancer

Epidermal growth factor receptor (EGFR) supports colorectal cancer progression via oncogenic signaling. Anti‐EGFR therapy is being investigated as a clinical option for colorectal cancer, and an observed interaction between EGFR and Prion protein has been detected in neuronal cells. We hypothesized...

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Publicat a:Mol Oncol
Autors principals: Atkinson, Caroline J., Kawamata, Futoshi, Liu, Cheng, Ham, Sunyoung, Győrffy, Balázs, Munn, Alan L., Wei, Ming Q., Möller, Andreas, Whitehall, Vicki, Wiegmans, Adrian P.
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2019
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6441932/
https://ncbi.nlm.nih.gov/pubmed/30478887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1878-0261.12411
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