Secreted cellular prion protein binds doxorubicin and correlates with anthracycline resistance in breast cancer

Anthracyclines are among the most effective chemotherapeutics ever developed, but they produce grueling side effects and serious adverse events, and resistance often develops over time. We found that these compounds can be sequestered by secreted cellular prion protein (PrP(C)), which blocks their c...

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Bibliographic Details
Published in:JCI Insight
Main Authors: Wiegmans, Adrian P., Saunus, Jodi M., Ham, Sunyoung, Lobb, Richard, Kutasovic, Jamie R., Dalley, Andrew J., Miranda, Mariska, Atkinson, Caroline, Foliaki, Simote T., Ferguson, Kaltin, Niland, Colleen, Johnstone, Cameron N., Lewis, Victoria, Collins, Steven J., Lakhani, Sunil R., Al-Ejeh, Fares, Möller, Andreas
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2019
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6483007/
https://ncbi.nlm.nih.gov/pubmed/30830863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.124092
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