Secreted cellular prion protein binds doxorubicin and correlates with anthracycline resistance in breast cancer

Anthracyclines are among the most effective chemotherapeutics ever developed, but they produce grueling side effects and serious adverse events, and resistance often develops over time. We found that these compounds can be sequestered by secreted cellular prion protein (PrP(C)), which blocks their c...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Wiegmans, Adrian P., Saunus, Jodi M., Ham, Sunyoung, Lobb, Richard, Kutasovic, Jamie R., Dalley, Andrew J., Miranda, Mariska, Atkinson, Caroline, Foliaki, Simote T., Ferguson, Kaltin, Niland, Colleen, Johnstone, Cameron N., Lewis, Victoria, Collins, Steven J., Lakhani, Sunil R., Al-Ejeh, Fares, Möller, Andreas
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6483007/
https://ncbi.nlm.nih.gov/pubmed/30830863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.124092
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