Secreted cellular prion protein binds doxorubicin and correlates with anthracycline resistance in breast cancer

Anthracyclines are among the most effective chemotherapeutics ever developed, but they produce grueling side effects and serious adverse events, and resistance often develops over time. We found that these compounds can be sequestered by secreted cellular prion protein (PrP(C)), which blocks their c...

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Vydáno v:JCI Insight
Hlavní autoři: Wiegmans, Adrian P., Saunus, Jodi M., Ham, Sunyoung, Lobb, Richard, Kutasovic, Jamie R., Dalley, Andrew J., Miranda, Mariska, Atkinson, Caroline, Foliaki, Simote T., Ferguson, Kaltin, Niland, Colleen, Johnstone, Cameron N., Lewis, Victoria, Collins, Steven J., Lakhani, Sunil R., Al-Ejeh, Fares, Möller, Andreas
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2019
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6483007/
https://ncbi.nlm.nih.gov/pubmed/30830863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.124092
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