Targeting the FOXO1/KLF6 axis regulates EGFR signaling and treatment response

EGFR activation is both a key molecular driver of disease progression and the target of a broad class of molecular agents designed to treat advanced cancer. Nevertheless, resistance develops through several mechanisms, including activation of AKT signaling. Though much is known about the specific mo...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Sangodkar, Jaya, Dhawan, Neil S., Melville, Heather, Singh, Varan J., Yuan, Eric, Rana, Huma, Izadmehr, Sudeh, Farrington, Caroline, Mazhar, Sahar, Katz, Suzanna, Albano, Tara, Arnovitz, Pearlann, Okrent, Rachel, Ohlmeyer, Michael, Galsky, Matthew, Burstein, David, Zhang, David, Politi, Katerina, DiFeo, Analisa, Narla, Goutham
التنسيق: Artigo
اللغة:Inglês
منشور في: American Society for Clinical Investigation 2012
الموضوعات:
Research Article
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC3386822/
https://ncbi.nlm.nih.gov/pubmed/22653055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI62058
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