Targeting the FOXO1/KLF6 axis regulates EGFR signaling and treatment response

EGFR activation is both a key molecular driver of disease progression and the target of a broad class of molecular agents designed to treat advanced cancer. Nevertheless, resistance develops through several mechanisms, including activation of AKT signaling. Though much is known about the specific mo...

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Detalhes bibliográficos
Main Authors: Sangodkar, Jaya, Dhawan, Neil S., Melville, Heather, Singh, Varan J., Yuan, Eric, Rana, Huma, Izadmehr, Sudeh, Farrington, Caroline, Mazhar, Sahar, Katz, Suzanna, Albano, Tara, Arnovitz, Pearlann, Okrent, Rachel, Ohlmeyer, Michael, Galsky, Matthew, Burstein, David, Zhang, David, Politi, Katerina, DiFeo, Analisa, Narla, Goutham
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3386822/
https://ncbi.nlm.nih.gov/pubmed/22653055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI62058
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