Introduction of the YTE mutation into the non-immunogenic HIV bnAb PGT121 induces anti-drug antibodies in macaques

Recombinant antibodies play increasingly important roles as immunotherapeutic treatments for human cancers as well as inflammatory and infectious diseases and have revolutionized their management. In addition, their therapeutic potential may be enhanced by the introduction of defined mutations in th...

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Bibliografiska uppgifter
I publikationen:PLoS One
Huvudupphovsmän: Rosenberg, Yvonne J., Lewis, George K., Montefiori, David C., LaBranche, Celia C., Lewis, Mark G., Urban, Lori A., Lees, Jonathan P., Mao, Lingjun, Jiang, Xiaoming
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2019
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6437720/
https://ncbi.nlm.nih.gov/pubmed/30785963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0212649
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