Introduction of the YTE mutation into the non-immunogenic HIV bnAb PGT121 induces anti-drug antibodies in macaques

Recombinant antibodies play increasingly important roles as immunotherapeutic treatments for human cancers as well as inflammatory and infectious diseases and have revolutionized their management. In addition, their therapeutic potential may be enhanced by the introduction of defined mutations in th...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Rosenberg, Yvonne J., Lewis, George K., Montefiori, David C., LaBranche, Celia C., Lewis, Mark G., Urban, Lori A., Lees, Jonathan P., Mao, Lingjun, Jiang, Xiaoming
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6437720/
https://ncbi.nlm.nih.gov/pubmed/30785963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0212649
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