Introduction of the YTE mutation into the non-immunogenic HIV bnAb PGT121 induces anti-drug antibodies in macaques

Recombinant antibodies play increasingly important roles as immunotherapeutic treatments for human cancers as well as inflammatory and infectious diseases and have revolutionized their management. In addition, their therapeutic potential may be enhanced by the introduction of defined mutations in th...

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Enregistré dans:
Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Rosenberg, Yvonne J., Lewis, George K., Montefiori, David C., LaBranche, Celia C., Lewis, Mark G., Urban, Lori A., Lees, Jonathan P., Mao, Lingjun, Jiang, Xiaoming
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2019
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6437720/
https://ncbi.nlm.nih.gov/pubmed/30785963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0212649
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