Fc-dependent functions are redundant to efficacy of anti-HIV antibody PGT121 in macaques

A considerable body of evidence suggests that Fc-dependent functions improve the capacity of broadly neutralizing antibodies (BnAbs) to protect against and control HIV-1 infection. This phenomenon, however, has not been formally tested in robust cell-associated macaque simian-human immunodeficiency...

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Foilsithe in:J Clin Invest
Main Authors: Parsons, Matthew S., Lee, Wen Shi, Kristensen, Anne B., Amarasena, Thakshila, Khoury, Georges, Wheatley, Adam K., Reynaldi, Arnold, Wines, Bruce D., Hogarth, P. Mark, Davenport, Miles P., Kent, Stephen J.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Clinical Investigation 2018
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6307963/
https://ncbi.nlm.nih.gov/pubmed/30475230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI122466
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