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Highly Diastereo- and Enantioselective Synthesis of Nitrile-Substituted Cyclopropanes by Myoglobin-Mediated Carbene Transfer Catalysis

A chemobiocatalytic strategy for the highly stereoselective synthesis of nitrile-substituted cyclopropanes is reported. The present approach relies on an asymmetric olefin cyclopropanation reaction catalyzed by an engineered myoglobin in the presence of ex situ generated diazoacetonitrile within a c...

詳細記述

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書誌詳細
出版年:Angew Chem Int Ed Engl
主要な著者: Chandgude, Ajay L., Fasan, Rudi
フォーマット: Artigo
言語:Inglês
出版事項: 2018
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6436623/
https://ncbi.nlm.nih.gov/pubmed/30300955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201810059
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