Manganese promotes the aggregation and prion-like cell-to-cell exosomal transmission of α-synuclein

The aggregation of α-synuclein (αSyn) is considered a key pathophysiological feature of certain neurodegenerative disorders, collectively termed synucleinopathies. Given that a prion-like, cell-to-cell transfer of misfolded αSyn has been recognized in the spreading of αSyn pathology in synucleinopat...

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Veröffentlicht in:Sci Signal
Hauptverfasser: Harischandra, Dilshan S., Rokad, Dharmin, Neal, Matthew L., Ghaisas, Shivani, Manne, Sireesha, Sarkar, Souvarish, Panicker, Nikhil, Zenitsky, Gary, Jin, Huajun, Lewis, Mechelle, Huang, Xuemei, Anantharam, Vellareddy, Kanthasamy, Arthi, Kanthasamy, Anumantha G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6435331/
https://ncbi.nlm.nih.gov/pubmed/30862700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aau4543
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