α-Synuclein Protects Against Manganese Neurotoxic Insult During the Early Stages of Exposure in a Dopaminergic Cell Model of Parkinson’s Disease

The pathological role of α-synuclein (α-Syn) aggregation in neurodegeneration is well recognized, but the physiological function of normal α-Syn remains unknown. As α-Syn protein contains multiple divalent metal binding sites, herein we conducted a comprehensive characterization of the role of α-Syn...

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Bibliografische gegevens
Gepubliceerd in:Toxicol Sci
Hoofdauteurs: Harischandra, Dilshan S., Jin, Huajun, Anantharam, Vellareddy, Kanthasamy, Arthi, Kanthasamy, Anumantha G.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2015
Onderwerpen:
Protective Role of Alpha-Synuclein in Manganese Neurotoxicity
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4306724/
https://ncbi.nlm.nih.gov/pubmed/25416158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfu247
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