Manganese promotes the aggregation and prion-like cell-to-cell exosomal transmission of α-synuclein

The aggregation of α-synuclein (αSyn) is considered a key pathophysiological feature of certain neurodegenerative disorders, collectively termed synucleinopathies. Given that a prion-like, cell-to-cell transfer of misfolded αSyn has been recognized in the spreading of αSyn pathology in synucleinopat...

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Vydáno v:Sci Signal
Hlavní autoři: Harischandra, Dilshan S., Rokad, Dharmin, Neal, Matthew L., Ghaisas, Shivani, Manne, Sireesha, Sarkar, Souvarish, Panicker, Nikhil, Zenitsky, Gary, Jin, Huajun, Lewis, Mechelle, Huang, Xuemei, Anantharam, Vellareddy, Kanthasamy, Arthi, Kanthasamy, Anumantha G.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6435331/
https://ncbi.nlm.nih.gov/pubmed/30862700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aau4543
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