Manganese Activates NLRP3 Inflammasome Signaling and Propagates Exosomal Release of ASC in Microglial Cells

Chronic sustained inflammation underlies many pathological conditions including neurodegenerative diseases. Divalent manganese (Mn) exposure can stimulate neurotoxicity by increasing inflammation. In this study, we examined whether Mn activates the NLRP3 inflammasome to prime neuroinflammation. Expo...

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Foilsithe in:Sci Signal
Main Authors: Sarkar, Souvarish, Rokad, Dharmin, Malovic, Emir, Luo, Jie, Harischandra, Dilshan S, Jin, Huajun, Anantharam, Vellareddy, Huang, Xuemei, Lewis, Mechelle, Kanthasamy, Arthi, Kanthasamy, Anumantha G.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2019
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6420319/
https://ncbi.nlm.nih.gov/pubmed/30622196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aat9900
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