Mitochondrial impairment in microglia amplifies NLRP3 inflammasome proinflammatory signaling in cell culture and animal models of Parkinson’s disease

The NLRP3 inflammasome signaling pathway is a major contributor to the neuroinflammatory process in the central nervous system. Oxidative stress and mitochondrial dysfunction are key pathophysiological processes of many chronic neurodegenerative diseases, including Parkinson’s disease (PD). However,...

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Publicado en:NPJ Parkinsons Dis
Main Authors: Sarkar, Souvarish, Malovic, Emir, Harishchandra, Dilshan S., Ghaisas, Shivani, Panicker, Nikhil, Charli, Adhithiya, Palanisamy, Bharathi N., Rokad, Dharmin, Jin, Huajun, Anantharam, Vellareddy, Kanthasamy, Arthi, Kanthasamy, Anumantha G.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5645400/
https://ncbi.nlm.nih.gov/pubmed/29057315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41531-017-0032-2
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