Fyn kinase regulates misfolded α-synuclein uptake and NLRP3 inflammasome activation in microglia

Persistent microglia-mediated neuroinflammation is a major pathophysiological contributor to the progression of Parkinson’s disease (PD), but the cell-signaling mechanisms governing chronic neuroinflammation are not well understood. Here, we show that Fyn kinase, in conjunction with the class B scav...

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Vydáno v:J Exp Med
Hlavní autoři: Panicker, Nikhil, Sarkar, Souvarish, Harischandra, Dilshan S., Neal, Matthew, Kam, Tae-In, Jin, Huajun, Saminathan, Hariharan, Langley, Monica, Charli, Adhithiya, Samidurai, Manikandan, Rokad, Dharmin, Ghaisas, Shivani, Pletnikova, Olga, Dawson, Valina L., Dawson, Ted M., Anantharam, Vellareddy, Kanthasamy, Anumantha G., Kanthasamy, Arthi
Médium: Artigo
Jazyk:Inglês
Vydáno: Rockefeller University Press 2019
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6547864/
https://ncbi.nlm.nih.gov/pubmed/31036561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20182191
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