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Manganese promotes the aggregation and prion-like cell-to-cell exosomal transmission of α-synuclein
The aggregation of α-synuclein (αSyn) is considered a key pathophysiological feature of certain neurodegenerative disorders, collectively termed synucleinopathies. Given that a prion-like, cell-to-cell transfer of misfolded αSyn has been recognized in the spreading of αSyn pathology in synucleinopat...
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| 出版年: | Sci Signal |
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| 主要な著者: | , , , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6435331/ https://ncbi.nlm.nih.gov/pubmed/30862700 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aau4543 |
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