Inhibition of DYRK1A-EGFR axis by p53-MDM2 cascade mediates the induction of cellular senescence

Activation of p53 may induce apoptosis or cellular senescence in stressed cells. We here report that epidermal growth factor receptor (EGFR) is downregulated by p53 activation in a subset of cancer cell lines, and this EGFR downregulation mediates cellular senescence caused by p53 activation. EGFR c...

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Bibliographic Details
Published in:Cell Death Dis
Main Authors: Xu, Xiuhua, Liu, Qiao, Zhang, Chen, Ren, Shuai, Xu, Limei, Zhao, Zixiao, Dou, Hao, Li, Peishan, Zhang, Xiyu, Gong, Yaoqin, Shao, Changshun
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6433862/
https://ncbi.nlm.nih.gov/pubmed/30910997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-1521-5
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