Resveratrol sequentially induces replication and oxidative stresses to drive p53-CXCR2 mediated cellular senescence in cancer cells

Resveratrol (RSV) acts either as an antioxidant or a pro-oxidant depending on contexts. RSV-treated cancer cells may experience replication stress that can lead to cellular senescence or apoptosis. While both oxidative and replication stresses may mediate the anti-proliferation effect of RSV, to wha...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Li, Boxuan, Hou, Dong, Guo, Haiyang, Zhou, Haibin, Zhang, Shouji, Xu, Xiuhua, Liu, Qiao, Zhang, Xiyu, Zou, Yongxin, Gong, Yaoqin, Shao, Changshun
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5428242/
https://ncbi.nlm.nih.gov/pubmed/28303009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-00315-4
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