Pharmacological inhibition of the NLRP3 inflammasome reduces blood pressure, renal damage, and dysfunction in salt-sensitive hypertension

AIMS: Renal inflammation, leading to fibrosis and impaired function is a major contributor to the development of hypertension. The NLRP3 inflammasome mediates inflammation in several chronic diseases by processing the cytokines pro-interleukin (IL)-1β and pro-IL-18. In this study, we investigated wh...

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Detalhes bibliográficos
Publicado no:Cardiovasc Res
Main Authors: Krishnan, Shalini M, Ling, Yeong H, Huuskes, Brooke M, Ferens, Dorota M, Saini, Narbada, Chan, Christopher T, Diep, Henry, Kett, Michelle M, Samuel, Chrishan S, Kemp-Harper, Barbara K, Robertson, Avril A B, Cooper, Matthew A, Peter, Karlheinz, Latz, Eicke, Mansell, Ashley S, Sobey, Christopher G, Drummond, Grant R, Vinh, Antony
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6432065/
https://ncbi.nlm.nih.gov/pubmed/30357309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvy252
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