Relaxin: Antifibrotic Properties and Effects in Models of Disease

Por Samuel, Chrishan S.
Publicado em 2005

Inotropic responses to human gene 2 (B29) relaxin in a rat model of myocardial infarction (MI): effect of pertussis toxin

Por Kompa, Andrew R, Samuel, Chrishan S, Summers, Roger J
Publicado em 2002

Relaxin Regulates Myofibroblast Contractility and Protects against Lung Fibrosis

Por Huang, Xiangwei, Gai, Ying, Yang, Naiheng, Lu, Baogen, Samuel, Chrishan S., Thannickal, Victor J., Zhou, Yong
Publicado em 2011

Human Umbilical Cord Mesenchymal Stem Cells Reduce Fibrosis of Bleomycin-Induced Lung Injury

Por Moodley, Yuben, Atienza, Daniel, Manuelpillai, Ursula, Samuel, Chrishan S., Tchongue, Jorge, Ilancheran, Sivakami, Boyd, Richard, Trounson, Alan
Publicado em 2009

Structural and functional correlations in a large animal model of bleomycin-induced pulmonary fibrosis

Por Organ, Louise, Bacci, Barbara, Koumoundouros, Emmanuel, Barcham, Garry, Milne, Marjorie, Kimpton, Wayne, Samuel, Chrishan, Snibson, Ken
Publicado no BMC Pulm Med (2015)

The Anti-fibrotic Actions of Relaxin Are Mediated Through a NO-sGC-cGMP-Dependent Pathway in Renal Myofibroblasts In Vitro and Enhanced by the NO Donor, Diethylamine NONOate

Por Wang, Chao, Kemp-Harper, Barbara K., Kocan, Martina, Ang, Sheng Yu, Hewitson, Tim D., Samuel, Chrishan S.
Publicado no Front Pharmacol (2016)

Epigenetic Modifications to H3K9 in Renal Tubulointerstitial Cells after Unilateral Ureteric Obstruction and TGF-β1 Stimulation

Por Hewitson, Timothy D., Holt, Stephen G., Tan, Sven-Jean, Wigg, Belinda, Samuel, Chrishan S., Smith, Edward R.
Publicado no Front Pharmacol (2017)

Synthetic Covalently Linked Dimeric Form of H2 Relaxin Retains Native RXFP1 Activity and Has Improved In Vitro Serum Stability

Por Nair, Vinojini B., Bathgate, Ross A. D., Separovic, Frances, Samuel, Chrishan S., Hossain, Mohammed Akhter, Wade, John D.
Publicado no Biomed Res Int (2015)

Serelaxin Elicits Bronchodilation and Enhances β-Adrenoceptor-Mediated Airway Relaxation

Por Lam, Maggie, Royce, Simon G., Donovan, Chantal, Jelinic, Maria, Parry, Laura J., Samuel, Chrishan S., Bourke, Jane E.
Publicado no Front Pharmacol (2016)

Does a Nephron Deficit Exacerbate the Renal and Cardiovascular Effects of Obesity?

Por Gurusinghe, Seshini, Brown, Russell D., Cai, Xiaochu, Samuel, Chrishan S., Ricardo, Sharon D., Thomas, Merlin C., Kett, Michelle M.
Publicado em 2013

Relaxin Signals through a RXFP1-pERK-nNOS-NO-cGMP-Dependent Pathway to Up-Regulate Matrix Metalloproteinases: The Additional Involvement of iNOS

Por Chow, Bryna Suet Man, Chew, Elaine Guo Yan, Zhao, Chongxin, Bathgate, Ross A. D., Hewitson, Tim D., Samuel, Chrishan S.
Publicado em 2012

The Minimal Active Structure of Human Relaxin-2

Por Hossain, Mohammed Akhter, Rosengren, K. Johan, Samuel, Chrishan S., Shabanpoor, Fazel, Chan, Linda J., Bathgate, Ross A. D., Wade, John D.
Publicado em 2011

Anti-Inflammatory Effects of Adult Stem Cells in Sustained Lung Injury: A Comparative Study

Por Moodley, Yuben, Vaghjiani, Vijesh, Chan, James, Baltic, Svetlana, Ryan, Marisa, Tchongue, Jorge, Samuel, Chrishan S., Murthi, Padma, Parolini, Ornella, Manuelpillai, Ursula
Publicado em 2013

Identification of Key Residues Essential for the Structural Fold and Receptor Selectivity within the A-chain of Human Gene-2 (H2) Relaxin

Por Chan, Linda J., Rosengren, K. Johan, Layfield, Sharon L., Bathgate, Ross A. D., Separovic, Frances, Samuel, Chrishan S., Hossain, Mohammed A., Wade, John D.
Publicado em 2012

Low‐dose maternal alcohol consumption: effects in the hearts of offspring in early life and adulthood

Por Nguyen, Vivian B., Probyn, Megan E., Campbell, Fiona, Yin, Kom V., Samuel, Chrishan S., Zimanyi, Monika A., Bertram, John F., Black, Mary Jane, Moritz, Karen M.
Publicado em 2014

Anti-fibrotic Potential of AT(2) Receptor Agonists

Por Wang, Yan, Del Borgo, Mark, Lee, Huey W., Baraldi, Dhaniel, Hirmiz, Baydaa, Gaspari, Tracey A., Denton, Kate M., Aguilar, Marie-Isabel, Samuel, Chrishan S., Widdop, Robert E.
Publicado no Front Pharmacol (2017)

ML290 is a biased allosteric agonist at the relaxin receptor RXFP1

Por Kocan, Martina, Sarwar, Mohsin, Ang, Sheng Y., Xiao, Jingbo, Marugan, Juan J., Hossain, Mohammed A., Wang, Chao, Hutchinson, Dana S., Samuel, Chrishan S., Agoulnik, Alexander I., Bathgate, Ross A. D., Summers, Roger J.
Publicado no Sci Rep (2017)

Colony-Stimulating Factor-1 Promotes Kidney Growth and Repair via Alteration of Macrophage Responses

Por Alikhan, Maliha A., Jones, Christina V., Williams, Timothy M., Beckhouse, Anthony G., Fletcher, Anne L., Kett, Michelle M., Sakkal, Samy, Samuel, Chrishan S., Ramsay, Robert G., Deane, James A., Wells, Christine A., Little, Melissa H., Hume, David A., Ricardo, Sharon D.
Publicado em 2011